Whether you are looking to dissolve dermal fillers due to dissatisfaction with your previous results or you are experiencing complications from dermal fillers, the providers at The Alchemy Clinic in Manchester, NH, are here to help. Asymmetry, lumps, migration, chronic swelling, and/or overcorrection of specific areas are common reasons why patients may seek to dissolve their hyaluronic acid-based dermal fillers. Other more serious complications that may prompt patients to seek care include vascular injuries such as occlusions, compression of vessels in the face, pain, or infections.

With facial ultrasound, we can more clearly define the location of the dermal filler and dissolve it directly under ultrasound guidance. This allows for optimal and precise removal of the dermal filler and eliminates the need for high doses of Hyaluronidase (Hylenex).


What Are the Risks and Side Effects of Hylenex Treatment?

Possible risks and side effects of Hyaluronidase treatment include bruising, swelling, and discomfort, as well as allergic reactions, although these are quite rare.Non-surgical aesthetic procedures are increasing, as is the rate of complications. We encourage all patients to thoroughly research their providers and carefully consider their choices before undergoing any non-surgical procedures.

Tips for your research include:

It's also important to remember that not all fillers are dissolvable, so we encourage all patients to inquire about the products that will be used before they are injected.

If you are experiencing an emergent complication, we recommend calling the office at 603.206.5804 during office hours or The Alchemy Clinic at 603.206.5804 or 603.724.7322 so we can coordinate immediate intervention.

What is Hyaluronidase and How Does It Dissolve Dermal Fillers?

Let’s start first with hyaluronic acid (HA). Hyaluronic acid is a naturally occurring substance in the body that hydrates and plumps the skin. It comprises a long chain of sugar molecules in connective tissues throughout the body. Given these properties, it is easy to understand why dermal fillers are made of synthetic HA.

Part of the body’s normal process of breaking down HA involves hyaluronidase. Certain cells, including white blood cells, produce this enzyme naturally in the body and break down HA molecules. Therefore, the medication Hyaluronidase (Hylenex) breaks down and dissolves hyaluronic acid-based dermal fillers.


Hyaluronidase is effective in dissolving hyaluronic acid-based dermal fillers. It is not effective for other types of fillers.
The effects of hyaluronidase can be seen almost immediately, usually within 24 to 48 hours.
Most patients experience some discomfort during the procedure. A topical anesthetic may be applied to alleviate pain.
If you experience any side effects or complications, it is imperative to contact your healthcare provider immediately for appropriate management and treatment.
The number of sessions required varies depending on the amount and type of filler that needs to be dissolved.
Yes, hyaluronidase can be used in smaller quantities to make minor adjustments to the results of a previous filler treatment.
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